Regulation of metabolic processes by oncogenic signalling, functional analysis of metabolic dependencies of cancer cells, regulation of lipid synthesis during cell growth and cell transformation, cellular energy control and stress response pathways, metabolomics and flux analysis

since 2018 Member “Hinterzartner Kreis” of the German Research Foundation (DFG)

2008-2011 EMBO Young Investigator Programme (EMBO YIP)

1997-1999 EMBO long-term fellowship

1. Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y. L. & Schulze, A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8, 224-236, doi:10.1016/j.cmet.2008.07.007 (2008).

2. Ros, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G., Howell, M., Zamboni, N. & Schulze, A. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2, 328-343, doi:10.1158/2159-8290.CD-11-0234 (2012).

3. Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., McGarry, L., James, D., Shanks, E., Kalna, G., Saunders, R. E., Jiang, M., Howell, M., Lassailly, F., Thin, M. Z., Spencer-Dene, B., Stamp, G., van den Broek, N. J., Mackay, G., Bulusu, V., Kamphorst, J. J., Tardito, S., Strachan, D., Harris, A. L., Aboagye, E. O., Critchlow, S. E., Wakelam, M. J., Schulze, A. & Gottlieb, E. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27, 57-71, doi:10.1016/j.ccell.2014.12.002 (2015).

4. Snaebjornsson, MT, Janaki-Raman, S, Schulze, A. Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer. Cell Metab (2019), doi: 10.1016/j.cmet.2019.11.010.

5. Kalogirou, C., Linxweiler, J., Schmucker, P., Snaebjornsson, M. T., Schmitz, W., Wach, S., Krebs, M., Hartmann, E., Puhr, M., Muller, A., Spahn, M., Seitz, A. K., Frank, T., Marouf, H., Buchel, G., Eckstein, M., Kubler, H., Eilers, M., Saar, M., Junker, K., Rohrig, F., Kneitz, B., Rosenfeldt, M. T. & Schulze, A. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun 12, 5066, doi:10.1038/s41467-021-25325-9 (2021).