The Steinmetz group develops experimental approaches to read, edit and write entire genomes across scales. By applying these technologies, members of the lab aim at understanding the genetic basis of complex phenotypes, the mechanisms of gene regulation and RNA splicing, and the molecular systems underpinning disease.

2019 – Co-founder, Recombia Biosciences, USA

2017 – Principal Investigator, German Center for Cardiovascular Research (DZHK)

2017 – Co-founder, Board of Directors, Levitas Bio, USA

2017 ERC Advanced Investigator (second consecutive award)

2016 Ira Herskowitz Award, Genetics Society of America

2014– Director, Life Science Alliance (research partnership between EMBL & Stanford)

2013 – Professor of Genetics, & Co-Director SGTC, Stanford University

2013 – EMBO Member

2012 ERC Advanced Investigator

2010 – Co-founder, Board of Directors (2011–2014), President of Scientific Advisory Board (2011–2019), Consultant, Sophia Genetics SA, CHE

2009 – Senior Scientist, EMBL

2003 – Group Leader, Genome Biology Unit (formerly Gene Expression), EMBL

1. Schraivogel D, Kuhn TM, Pausen Malte, Oy K, Middelbrook A, Tischer C, Ramasz B, Ordonez-Rueda D, Dees M, Cuylen Haering S, Diebold E, Steinmetz LM: High-speed fluorescence image-enabled cell sorting. Science, 2022

2. Zhu C, Wu J, Sun H, Briganti F, Meder B, Wie W, Steinmetz LM: Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Nat Commun 12:4203, 2021

3. Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, Karakikes I, Rego S, Cipriano A, Snyder M, Meder B, Xu Z, Millat G, Gotthard M, Mercola M, Steinmetz LM: iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Rep 32(10):108117, 2020

4. Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ; Wanek Program Preclinical Pipeline: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat Med 26(11):1788-1800, 2020

5. Schraivogel D, Gschwind AR, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM: Targeted Perturb-seq enables genome-scale genetic screens in single cells. Nat Methods 17(6):629-35, 2020