Plasmalemmal and organellar TRP and Ca2+ channels

channelopathies

cardiac function and remodeling

transgenic approaches and genome editing

1. 2015–2019 Coordinator Heidelberg for PharmCompNet BW: Kompetenznetzwerk Pharmakologie Baden-Württemberg - Wirkstoffnetzwerke als Grundlagen der individualisierten Arzneistofftherapie

2. 2006–2011 Member (2009-2011 chairmen) of the Animal Welfare Committee of the Saarland for the evaluation of animal experiments

3. 2006–2011 Vice-Chairman of the DFG Graduate School 1326 “Calcium Signaling and Cellular Nanodomains“

4. 2012 – Member, “Ethikkommission“ of the Medical Faculty, Heidelberg University

5. 2021 – Associate Editor of American Chemical Society (ACS) Pharmacology & Translational Science

6. 2018 – Editorial board, Cell Calcium

1. Medert R, Thumberger T, Tavhelidse-Suck T, Hub T, Kellner T, Oguchi Y, Dlugosz S, Zimmermann F, Wittbrodt J, Freichel M: Efficient single copy integration via homology-directed repair (scHDR) by 5'modification of large DNA donor fragments in mice. Nucleic Acids Res. 2023 Feb 22;51(3):e14.

2. Medert R, Pironet A, Bacmeister L, Segin S, Londoño Camacho JE, Vennekens R, Freichel M: Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart. Basic Res Cardiol. 2020 115:70

3. Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M*, Lipp P* (2015). A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. Eur Heart J, 36: 2257 – 66. *shared senior authorship

4. Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londono JE, Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M (2010): Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest, 120, 3267-79.

5. Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B (2001). Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol. 3, 121-127