B10: Deciphering molecular circuits of cardiac remodeling and dysfunction via an integrative reverse approach
Project B10 is a canonical data integration project aiming to identify key molecular circuits for cardiac remodeling and dysfunction. B10 will develop and apply novel and state of the art computational methods to integrate bulk and single-cell OMICs data from several dedicated mouse models as well as public data from patients. From these analyses we will generate and experimentally validate hypotheses with a focus on reverse remodeling as opposed to adverse remodeling and contractile dysfunction.
