Transcriptional control and spatial chromatin organization in cardiac cells in development and disease, functional genomics, data sciences

2022 PI of the CRC 1550 ‘Molecular Circuits of Heart Disease’

2022 DZHK and full Professor at the University of Heidelberg

2021-22 Faculty Member of the International Max Planck Research School for Molecular Organ Biology, Bad Nauheim

2019-22 Associate Professor for Cardiac Regulation at the Center of Physiology, Goethe-University Frankfurt

2020 PI of the CRC 1425 ‘ScarCare’

2020 Guido Tarrone Award der Heart Failure Association of the European Society of Cardiology

1. Hesse M, Bednarz R, Carls E, Becker C, Bondareva O, Lother A, Geisen C, Dreßen M, Krane M, Roell W, Hein L, Fleischmann BK, Gilsbach R. Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. J Mol Cell Cardiol 152:95-104, 2021

2. Gilsbach R, Schwaderer M, Preissl S, Grüning BA, Kranzhöfer D, Schneider P, Nührenberg TG, Mulero-Navarro S, Weichenhan D, Braun C, Dreßen M, Jacobs AR, Lahm H, Doenst T, Backofen R, Krane M, Gelb BD, Hein L. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. Nat Commun 26;9(1):391, 2018

3. Nothjunge S, Nührenberg TG, Grüning BA, Doppler SA, Preissl S, Schwaderer M, Rommel C, Krane M, Hein L, Gilsbach R. DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes. Nat Commun 8(1):1667, 2017

4. Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circ Res 117(5):413-23, 2015

5. Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nat Commun 2014 Oct 22;5:5288. doi: 10.1038/ncomms6288. PMID: 25335909; PMCID: PMC4220495.