Prof. Dr.

Lars Steinmetz

Projects:

European Molecular Biology Laboratory (EMBL)
Germany
Meyerhofstraße 1
69117 Heidelberg

Research Interests

The Steinmetz group develops experimental approaches to read, edit and write entire genomes across scales. By applying these technologies, members of the lab aim at understanding the genetic basis of complex phenotypes, the mechanisms of gene regulation and RNA splicing, and the molecular systems underpinning disease.

Selected Coordinating Functions and Awards

2024

Chair, Genetics Department, Stanford University

2023

Dieter Schwarz Foundation Endowed Professorship, Stanford University

2017

Principal Investigator, German Center for Cardiovascular Research (DZHK)

2017

ERC Advanced Investigator (second consecutive award)

2016

Ira Herskowitz Award, Genetics Society of America

2015

Director, Life Science Alliance (research partnership between EMBL & Stanford)

2013

Professor of Genetics, & Co-Director SGTC, Stanford University

2013

EMBO Member

2009

Senior Scientist, EMBL

2003

Group Leader, Genome Biology Unit (formerly Gene Expression), EMBL

CRC1550 Related Publications

2026

Dysregulated Ribonucleoprotein Granules Impair Mitochondrial Function in RBM20-Related Dilated Cardiomyopathy

Kornienko J, Müller LH, Nickel A, Kohlhaas M, Börmel M, Alfonso-Gonzalez C, Oorschot VMJ, Fungate M, Lewey S, Kees J, Müller J, Lindenhofer D, Fenzl K, Schraft L, Clauder-Münster S, Konrad L, Haberkant P, Montoya FDM, Dauksaite V, Gotthardt M, van den Hoogenhof MMG, Maack C, Steinmetz LM.

Circulation. 2026 Sep 15.

2026

Sarcomeric Remodelling in Human Heart Failure unraveled by single molecule long read sequencing

Jan Haas, Sarah Schudy, Benedikt Rauscher, Ana Munoz, Steffen Roßkopf,Christoph Reich, Gizem Donmez Yalcin, Abdullah Yalcin, Timon Seeger, Manuel H. Taft, Marc Freichel, Dirk Grimm, Dietmar Manstein, Johannes Backs, Norbert Frey, Lars Steinmetz, Benjamin Meder.

EMBO Mol Med. 2026.

2025

AAV9-Mediated TNPO3 Overexpression in the Heart Rescues RBM20 Cardiomyopathy in Mice

Kornienko, J., Schraft, L., Fenzl, K., van den Hoogenhof, MMG, Steinmetz, LM.

Circulation. 2025, 152(10), 739.

2023

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

Kornienko, J., Rodríguez-Martínez, M., Fenzl, K., Hinze, F., Schraivogel, D., Grosch, M., Tunaj, B., Lindenhofer, D., Schraft, L., Kueblbeck, M., Smith, E., Mao, C., Brown, E., Owens, A., Saguner, AM, Meder, B., Parikh, V., Gotthardt, M., & Steinmetz, LM.

Nature communications. 2023, 14, 4312.

2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Kramer C, Clauder-Munster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D & Steinmetz LM.

Nat Commun. 14:3714, 2023.

2022

Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy

Lennermann DC, Pepin ME, Grosch M, Konrad L, Kemmling E, Hartmann J, Nolte JL, Clauder-Munster S, Kayvanpour E, Sedaghat-Hamedani F, Haas J, Meder B, van den Boogaard M, Amin AS, Dewenter M, Kruger M, Steinmetz LM, Backs J & van den Hoogenhof MMG.

Am J Physiol Heart Circ Physiol. 323:H1296-H310, 2022.