Dr.

Maarten van den Hoogenhof

Projects:

Junior Research Group Leader
Institute of Experimental Cardiology
Medical Faculty Heidelberg, Heidelberg University
Germany
Eppelheimer Straße 8
69115 Heidelberg

Phone: +49-6221-56-32147

Email: [email protected]

Research Interests

RNA biology, RNA splicing, molecular biology, cardiac development and disease.

Selected Coordinating Functions and Awards

Since 2022

Junior Research Group leader at Innovationcampus Region Rhein Neckar, Institute of Experimental Cardiology, Heidelberg

2021-2022

Member of the DZHK Preclinical Digitalization Taskforce

2019-2023

Member of the Young DZHK Postdoc committee, partner site Heidelberg/Mannheim

2019

DZHK (German Center for Cardiovascular Research) Postdoc Start-Up grant

2019

DGK (German Society of Cardiology) Research Stipendium

2019

DFG (German Research Foundation) Research Grant

2018

Precision Medicine Award (1st prize), DZHK Precision Medicine in Cardiomyopathies and Heart Failure Summit 2018, Heidelberg

2018

Guido Tarone Award, HFA Winter meeting, Heart Failure Association of the European Society of Cardiology, Les Diablerets

2016

de Bakker Award, best contributor to departmental meeting debates

2009

Dr. E. Dekker Student Fellowship, Dutch Heart Foundation

CRC1550 Related Publications

2026

Novel Truncating Variant c.1222DupC in RBM20 Causes Cardiomyopathy Consistent With Haploinsufficiency

Pant P, Huang Y, Ghouse Z, Bai F, Kemmling E, Konrad L, Alameldeen A, Kistler R, Seeger T, Gotthardt M, Parikh VN, van den Hoogenhof MMG.

Circ Genom Precis Med. 19(4):e005471, 2026.

2026

CAMK2D causes heart failure in mice with RBM20 cardiomyopathy

van den Hoogenhof MMG, Duran J, Britto-Borges T, Sequeira V, Kemmling E, Konrad L, Schreiter F, Lennermann DC, Hartmann J, Schraft L, Kornienko J, Bock T, Krüger M, Maack C, Dieterich C, Steinmetz LM, Dewenter M, Backs J.

Nat Cardiovasc Res. 5(5):479-491, 2026.

2026

Dysregulated Ribonucleoprotein Granules Impair Mitochondrial Function in RBM20-Related Dilated Cardiomyopathy

Kornienko J, Müller LH, Nickel A, Kohlhaas M, Börmel M, Alfonso-Gonzalez C, Oorschot VMJ, Fungate M, Lewey S, Kees J, Müller J, Lindenhofer D, Fenzl K, Schraft L, Clauder-Münster S, Konrad L, Haberkant P, Montoya FDM, Dauksaite V, Gotthardt M, van den Hoogenhof MMG, Maack C, Steinmetz LM.

Circulation. 2026 Sep 15.

2025

AAV9-Mediated TNPO3 Overexpression in the Heart Rescues RBM20 Cardiomyopathy in Mice

Kornienko, J., Schraft, L., Fenzl, K., van den Hoogenhof, MMG, Steinmetz, LM.

Circulation. 2025, 152(10), 739.

2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Kramer C, Clauder-Munster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D & Steinmetz LM.

Nat Commun. 14:3714, 2023.

2022

Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy

Lennermann DC, Pepin ME, Grosch M, Konrad L, Kemmling E, Hartmann J, Nolte JL, Clauder-Munster S, Kayvanpour E, Sedaghat-Hamedani F, Haas J, Meder B, van den Boogaard M, Amin AS, Dewenter M, Kruger M, Steinmetz LM, Backs J & van den Hoogenhof MMG.

Am J Physiol Heart Circ Physiol. 323:H1296-H310, 2022.