Prof. Dr. Med.

Marc Freichel

Projects:

B09

IRTG

Institute of Pharmacology
Medical Faculty Heidelberg, Heidelberg University
Germany
Im Neuenheimer Feld 669
69120 Heidelberg

Phone: +49-6221-54-86861

Email: marc.freichel@pharma.uni-heidelberg.de

Research Interests

Plasmalemmal and organellar TRP and Ca2+ channels, channelopathies, cardiac function and remodelling, transgenic approaches and genome editing.

Selected Coordinating Functions and Awards

2024

Member of the Review Board for Medicine of the German Research Foundation (DFG)

2023

Member of the Board of the German Society for Pharmacology (DGP)

Since 2021

2nd Chairman of the Continuing Education Commission of Pharmacology of the German Society for Pharmacology (DGP)

Since 2019

Faculty Council of the Faculty of Medicine, Heidelberg University

2015-2019

Coordinator Heidelberg for PharmCompNet BW: Kompetenznetzwerk Pharmakologie Baden-Württemberg - Wirkstoffnetzwerke als Grundlagen der individualisierten Arzneistofftherapie

2006-2011

Member (2009-2011 chairmen) of the Animal Welfare Committee of the Saarland for the evaluation of animal experiments

2006-2011

Vice-Chairman of the DFG Graduate School 1326 “Calcium Signaling and Cellular Nanodomains“

Since 2012

Member, “Ethikkommission“of the Medical Faculty, Heidelberg University

Since 2021

Associate Editor of American Chemical Society (ACS) Pharmacology & Translational Science

2019-2022

Editorial board, Journal of Molecular and Cellular Cardiology

Since 2018

Editorial board, Cell Calcium

CRC1550 Related Publications

2023

Efficient single copy integration via homology-directed repair (scHDR) by 5’modification of large DNA donor fragments in mice

Medert R, Thumberger T, Tavhelidse-Suck T, Hub T, Kellner T, Oguchi Y, Dlugosz S, Zimmermann F, Wittbrodt J & Freichel M

Nucleic Acids Res. 51:e14, 2023.

2024

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage

Tsvilovskyy V, Ottenheijm R, Kriebs U, Schutz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, Bock J, Jaslan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, Weissgerber P, Vogt D, Eberhagen C, Mannebach S, Berlin M, Kuryshev V, Schumacher D, Philippaert K, Camacho-Londono JE, Mathar I, Dieterich C, Klugbauer N, Biel M, Wahl-Schott C, Lipp P, Flockerzi V, Zischka H, Algul H, Lechner SG, Lesina M, Grimm C, Fakler B, Schulte U, Muallem S & Freichel M.

J Clin Invest. 134:2024

2023

Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo

Varma, E., J. Burghaus, T. Schwarzl, T. Sekaran, P. Gupta, A.A. Gorska, C. Hofmann, C. Stroh, L. Jürgensen, V. Kamuf-Schenk, X.Li, R. Medert, F. Leuschner, V. Kmietczyk, H.A. Katus, M.W. Hentze, N. Frey and M. Völkers.

Basic Res Cardiol. 118:25, 2023