Advancing cardiovascular medicine depends on standardized in vivo and hiPSC-based in vitro models that reliably recapitulate human heart disease. S02 combines small-animal and hiPSC-derived models of genetic and acquired cardiac diseases with state-of-the-art bioengineered platforms. Building on established systems, we will introduce pharmacotherapy regimens, broaden multi-organ profiling, and advance heterocellular 2D/3D models (e.g. EHTs, microtissues), organ-on-chip technologies to generate robust, reproducible disease models for translational research.
