Projects A05 and A06 from the first funding period are now merged into a single project A06, due to their overlapping interests and complementing expertise. In the second funding period, we have 3 main aims (Figure 1). First, we will investigate whether cytoplasmic granule formation is a potential disease driver beyond RBM20’s loss-of-splicing. Second, we will characterize the composition of these granules, both on protein and RNA level, and investigate how these granules affect protein production. Finally, we will examine how fibroblasts, immune cells, and other non-cardiomyocytes contribute to disease development and progression.
Figure 1.
